Detecting Enzyme Activities with Exogenous MRI Contrast Agents
نویسندگان
چکیده
منابع مشابه
Switching of MRI Contrast Agents with Ultrasound
Purpose The utility of (super)paramagnetic agents to enhance contrast in MRI has been for some time demonstrated in human studies. The contrast provided by these agents arises from their ability to achieve reductions in T1 and T2*. Another approach to designing contrast agents is to consider the use of ultrasound (US). We have developed a method involving the application of US in MRI in the pre...
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Amphiphilic triblock copolymers containing Fe(III) -catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide rang...
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Liver specific contrast media (LSCM) can be subdivided according to different modalities of hepatic distribution: exclusive distribution to the hepatocellular compartment can be obtained using CM which accumulate within the hepatocytes after slow infusion; other CM demonstrate combined perfusion and hepatocyte-selective properties, with an initial distribution to the vascular-interstitial compa...
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Objective(s): This study describes the preparation, biodistribution of 153Sm-DTPA-SPION after intravenous injection in rats. Materials and Methods: The chelator DTPA dianhydride was conjugated to SPION using a small modification of the well-known cyclic anhydride method. Conjugation was done at a 1: 4 (SPION: ccDTPA) molar ratio. Conjugation reaction was purified with magnetic assorting column...
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Introduction Recently it was shown that top-down microfabrication could be used to engineer precisely shaped magnetic microparticles that function as MRI contrast agents with tunable NMR spectral signatures [1]. The agents operated similarly to CEST / PARACEST agents [2,3], except with continuously tunable frequency shifts determined by control of the particle geometry, and with a magnetization...
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2014
ISSN: 0947-6539
DOI: 10.1002/chem.201402474